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SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways: Methylation (contributing methyl groups to activate certain molecules) The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)34-36 In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine. SAMe has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs large numbers of complex enzymatic reactions continually. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.